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Item number: Cay14309-5

ANA-12 is a TrkB receptor antagonist that prevents activation of the receptor by BDNF with IC50 values of 45.6 nM and 41.1 µM for the high and low affinity sites of the receptor, respectively. It does not affect TrkA or TrkC in an assay of neurite outgrowth. Mice administered ANA-12 demonstrated reduced anxiety- and...

Keywords:	N-[2-[[(hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]-benzo[b]thiophene-2-carboxamide
Application:	TrkB antagonist
CAS	219766-25-3
MW:	407.5 D

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ANA-12

Item number: TGM-T2359-100mg

Description: ANA-12 is a potent and selective TrkB antagonist that exhibits anxiolytic and antidepressant activity in mice. Target: Trk receptor. Smiles: O=C(Nc1ccccc1C(=O)NC1CCCCNC1=O)c1cc2ccccc2s1. References: Cazorla M, et al. J Clin Invest. 2011, 121(5), 1846-1857.

Keywords:	ANA 12, ANA12
CAS	219766-25-3
MW:	407.49 D

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