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Amodiaquine is a prodrug form of the antimalarial compound N-desethyl amodiaquine (Cay-20822). It is active against several strains of P. falciparum in vitro (EC50s = 0.23-0.52 nM) and exhibits a synergistic effect when used in combination with N-desethyl amodiaquine. Amodiaquine dose-dependently inhibits development of parasitemia in a mouse model of P. berghei infection.Formal Name: 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-phenol. CAS Number: 86-42-0. Synonyms: Camoquine, Flavoquine, NSC 13453, SN 10751. Molecular Formula: C20H22ClN3O. Formula Weight: 355.9. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2.5 mg/ml, DMSO: 5 mg/ml, Ethanol: 2 mg/ml. lambdamax: 224, 343 nm. SMILES: OC(C=C1)=C(CN(CC)CC)C=C1NC2=CC=NC3=C2C=CC(Cl)=C3. InChi Code: InChI=1S/C20H22ClN3O/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19/h5-12,25H,3-4,13H2,1-2H3,(H,22,23). InChi Key: OVCDSSHSILBFBN-UHFFFAOYSA-N.
Keywords:
Camoquine, Flavoquine, NSC 13453, SN 10751, 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-phenol
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