51 products were found matching "K00546"!

In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the...

1-Methylhistamine is a major metabolite of histamine by histamine N-methyltransferase in the pathway of histidine metabolism. It has been used as a biomarker of histaminergic system activity in the brains of Alzheimer's disease patients as well as those with hypersomnia and other neurological conditions.Formal Name:...

Metoprine is an inhibitor of histamine N-methyltransferase (HNMT, IC50 = 91 nM). It is also an inhibitor of dihydrofolate reductase (Dhfr, IC50s = 1, 1. and 60 µM for the chicken, rat, and T. equiperdum enzymes, respectively). Metoprine (10 mg/kg) increases the levels of histamine in mouse cerebral cortex,...

Amodiaquine is a prodrug form of the antimalarial compound N-desethyl amodiaquine (Cay-20822). It is active against several strains of P. falciparum in vitro (EC50s = 0.23-0.52 nM) and exhibits a synergistic effect when used in combination with N-desethyl amodiaquine. Amodiaquine dose-dependently inhibits...

Protein function: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. [The UniProt Consortium]

Protein function: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. [The UniProt Consortium]

Protein function: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. [The UniProt Consortium]

Amodiaquine-d10 is intended for use as an internal standard for the quantification of amodiaquine (Cay-15954) by GC- or LC-MS. Amodiaquine is a prodrug form of the antimalarial compound N-desethyl amodiaquine (Cay-20822). It is active against several strains of P. falciparum in vitro (EC50s = 0.23-0.52 nM) and...

Protein function: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 88% and...

Protein function: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 83% and...

Organism: Mus musculus (Mouse). Source: E.coli. Expression Region: 1-295aa. Protein Length: Full Length. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: MASCMRSLFS DQGRYVESFR RFLNNSTEHQ CMQEFMDKKL PGIIARIGEA KAEIKILSVG GGAGEVDLQI LSKVQAQYPG ICINNEVVEP SAEQIVKYKE LVAKTSNMEN...

Description: 1-Methylhistamine dihydrochloride is a major metabolite of histamine by histamine N-methyltransferase in the pathway of histidine metabolism. It has been used as a biomarker of histaminergic system activity in the brains of Alzheimer's disease patients as well as those with hypersomnia and other...