AG-82

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds that act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation. AG-82 is an inhibitor of epidermal growth factor receptor kinase with an IC50 value of 3 µM in the human epidermoid carcinoma cell line A431.Formal Name: 2-[(3,4,5-trihydroxyphenyl)methylene]-propanedinitrile. CAS Number: 118409-58-8. Synonyms: NSC 676484, RG-50875, Tyrphostin 25, Tyrphostin AG-82. Molecular Formula: C10H6N2O3. Formula Weight: 202.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 0.15 mg/ml. lambdamax: 250, 389 nm. SMILES: OC1=CC(/C=C(C#N)/C#N)=CC(O)=C1O. InChi Code: InChI=1S/C10H6N2O3/c11-4-7(5-12)1-6-2-8(13)10(15)9(14)3-6/h1-3,13-15H. InChi Key: YZOFLYUAQDJWKV-UHFFFAOYSA-N.