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Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds that act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation. AG-213 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 2.4 µM in the human epidermoid carcinoma cell line A431. Formal Name: 2-cyano-3-(3,4-dihydroxyphenyl)-2E-propenethioamide. CAS Number: 122520-86-9. Synonyms: Tyrphostin AG-213, Tyrphostin 47. Molecular Formula: C10H8N2O2S. Formula Weight: 220.2. Purity: >97%. Formulation: A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2)(1:1): 0.5 mg/ml, Ethanol: 10 mg/ml. lambdamax: 249, 323, 392 nm. SMILES: N#C/C(=C\c1ccc(O)c(O)c1)/C(=S)N. InChi Code: InChI=1S/C10H8N2O2S/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+. InChi Key: ZGHQGWOETPXKLY-XVNBXDOJSA-N.