AG-17

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of protein tyrosine kinases. Tyrphostins are a class of antiproliferative compounds which act as protein tryrosine kinase blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation. AG-17 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 460 µM in the human epidermoid carcinoma cell line A431.Formal Name: 2-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-propanedinitrile. CAS Number: 10537-47-0. Synonyms: GCP 5126, Malonoben, NSC 242557, RG-50872, SF 6847, Tyrphostin 9, Tyrphostin AG-17. Molecular Formula: C18H22N2O. Formula Weight: 282.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO: PBS (pH 7.2)(1:6): 0.15 mg/ml, Ethanol: 12 mg/ml. lambdamax: 249, 365, 466 nm. SMILES: CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(/C=C(C#N)\C#N)=C1. InChi Code: InChI=1S/C18H22N2O/c1-17(2,3)14-8-12(7-13(10-19)11-20)9-15(16(14)21)18(4,5)6/h7-9,21H,1-6H3. InChi Key: MZOPWQKISXCCTP-UHFFFAOYSA-N.