Adrenorphin (human, mouse, rat, bovine) (trifluoroacetate salt)

Adrenorphin is an octapeptide agonist of µ-opioid receptors that is involved in nociception. It is a C-terminally amidated cleavage product corresponding to amino acids 210-218 of human proenkephalin A. It was originally found in a human pheochromocytoma but has also been found in the rat adrenal medulla and the rat olfactory bulb, hypothalamus, and striatum, among other brain regions. Adrenorphin selectively binds to µ-opioid receptors over kappa- and delta-opioid receptors (Kis = 0.12, 0.248, and 2.65 nM, respectively, in a radioligand binding assay). Intracerebroventricular administration of adrenorphin (6.1 nmol/animal) increases the latency to paw licking in the hot plate test in mice, indicating analgesic activity, an effect that can be reduced by the non-selective opioid receptor antagonist naloxone. It also induces respiratory depression in mice and rabbits (ED50s = 6 and 71.1 nmol/animal, respectively).Formal Name: L-tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-arginyl-L-arginyl-L-valinamide, trifluoroacetate salt. Synonyms: Met5-Enkephalin-Arg6-Arg7-Val8-NH2, Metorphamide, Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2. Molecular Formula: C44H69N15O9 . XCF3COOH. Formula Weight: 952.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: CC(C)[C@@H](C(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCSC)NC([C@@H](NC(CNC(CNC([C@@H](N)CC1=CC=C(C=C1)O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C44H69N15O9S.C2HF3O2/c1-25(2)36(37(46)63)59-41(67)31(12-8-19-52-44(49)50)57-39(65)30(11-7-18-51-43(47)48)56-40(66)32(17-20-69-3)58-42(68)33(22-26-9-5-4-6-10-26)55-35(62)24-53-34(61)23-54-38(64)29(45)21-27-13-15-28(60)16-14-27,3-2(4,5)1(6)7/h4-6,9-10,13-16,25,29-33,36,60H,7-8,11-12,17-24,45H2,1-3H3,(H2,46,63)(H,53,61)(H,54,64)(H,55,62)(H,56,66)(H,57,65)(H,58,68)(H,59,67)(H4,47,48,51)(H4,49,50,52),(H,6,7)/t29-,30-,31-,32-,33-,36-,/m0./s1. InChi Key: QAXMQVLLILLPAV-MWIHCNFISA-N.