372 products were found matching "K04215"!

Recombinant CHO-K1 cells stably overexpress human opioid receptor mu 1 (OPRM1) on the surface and contain high levels of G protein Galphai and Galphaq to couple with the receptor in downstream signaling pathways.

Small compounds (drugs or peptides) are not sufficiently complex by themselves to induce an immune response or be processed in a manner that elicits production of specific antibodies. For antibody production to be successful with small antigens, they must be chemically conjugated with immunogenic carrier proteins...

SR 17018 is an orally bioavailable and brain-penetrant agonist of µ-opioid receptors. It is functionally selective for G protein-coupled receptor signaling (EC50 = 97 nM for GTPgammaS binding in CHO cells expressing µ-opioid receptors) over beta-arrestin 2 recruitment (EC50 = >10,000 nM) at the µ-opioid receptor. SR...

A µ- and kappa-opioid receptor antagonist (Kis = 0.91 and 1.03 nM, respectively, in CHO membranes expressing the human receptors), selective for µ- and kappa-opioid receptors over delta-opioid receptors (Ki = 13.26 nM in CHO membranes expressing the human receptors), decreases self-administration of alcohol in...

An internal standard for the quantification of O-desmethyl-cis-tramadol by GC- or LC-MS, intended for research and forensic applications. Formulation: A 100 µg/ml solution in methanol. InChI:...

A mu-opioid agonist that is an antidiarrhoeal drug which inhibits intestinal motility and secretion. It has been shown to suppress the calcium-influx in dorsal root ganglion neurons.

meta-Methylfentanyl-d5 (hydrochloride) (Cay-42416) is intended for use as an internal standard for the quantification of meta-Methylfentanyl (Cay-22633, Cay-36371) by GC- or LC-MS. meta-Methylfentanyl is an analytical reference standard categorized as an opioid. meta-Methylfentanyl-d5 is regulated as a Schedule I...

meta-Fluorofentanyl-d5 (hydrochloride) (Cay-42429) is intended for use as an internal standard for the quantification of meta-fluorofentanyl (Cay-19424, Cay-38142) by GC- or LC-MS. meta-Fluorofentanyl is categorized as an opioid. meta-Fluorofentanyl-d5 is regulated as a Schedule I compound in the United States. This...

3,4-MDiPA (hydrochloride) (Cay-42415) is an analytical reference standard categorized as an amphetamine. 3,4-MDiPA has analgesic activity in mice. This product is intended for research and forensic applications.. Solulibility: PBS (pH 7.2): Sparingly soluble: 1-10 mg/ml: .

para-Methylfentanyl-d5 (hydrochloride) (Cay-42417) is intended for use as an internal standard for the quantification of para-methylfentanyl (Cay-41384, Cay-20038) by GC- or LC-MS. para-Methylfentanyl is categorized as an opioid. It has antinociceptive activity. para-Methylfentanyl is regulated as a Schedule I...

Naloxonazine is a µ-opioid receptor antagonist (Ki = 0.054 nM in a radioligand binding assay). It is selective for µ-opioid over kappa- and delta-opioid receptors (Kis = 11 and 8.6 nM, respectively, in radioligand binding assays) and selectively binds to high-affinity µ1-opioid over µ- and delta-opioid receptors...

DAMGO is a selective peptide agonist of the µ-opioid receptor (Kis = 1.18, 1,430, and 213 nM for human µ-, delta-, and kappa-opioid receptors, respectively). DAMGO displays higher efficacy than morphine (Cay-ISO60147) for µ-opioid-induced nociception in rats.Formal Name:...