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ABL 127 is a covalent aza-beta-lactam inhibitor of protein phosphatase methylesterase-1 (PME-1, IC50 = 4.2 nM). It selectively inhibits PME-1 over 50 other serine hydrolases in MDA-MB-231 and HEK293T cell lysates at 10 µM. ABL 127 decreases proliferation of Ishikawa cells and migration of ECC-1 endometrial carcinoma cells when used at a concentration of 50 nM.Formal Name: (3R)-3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine-1,2-dicarboxylic acid, 1,2-dimethyl ester. CAS Number: 1073529-41-5. Molecular Formula: C17H20N2O5. Formula Weight: 332.4. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMSO: >5mg mL, Ethanol: >1mg/mL. SMILES: COC(N(N(C(OC)=O)[C@@]1(C2=CC=CC=C2)C3CCCC3)C1=O)=O. InChi Code: InChI=1S/C17H20N2O5/c1-23-15(21)18-14(20)17(13-10-6-7-11-13,19(18)16(22)24-2)12-8-4-3-5-9-12/h3-5,8-9,13H,6-7,10-11H2,1-2H3/t17-/m0/s1. InChi Key: ZRHWCAFAIHTQKD-KRWDZBQOSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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