A-66

A-66 is a potent, selective inhibitor of the PI3K isoform p110alpha (IC50 = 32 nM in a cell-free assay). It displays over 100-fold selectivity for p110alpha over other isoforms. A-66 is effective in vivo, suppressing the growth of SKOV3 tumor xenografts in mice. It also impairs all measures of in vivo insulin action in mice. A-66 partially suppresses B cell receptor-dependent Akt activation and proliferation.Formal Name: (2S)-N1-[2-(1,1-dimethylethyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide. CAS Number: 1166227-08-2. Molecular Formula: C17H23N5O2S2. Formula Weight: 393.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 306 nm. SMILES: CC1=C(C2=CSC(C(C)(C)C)=N2)SC(NC(N3CCC[C@H]3C(N)=O)=O)=N1. InChi Code: InChI=1S/C17H23N5O2S2/c1-9-12(10-8-25-14(20-10)17(2,3)4)26-15(19-9)21-16(24)22-7-5-6-11(22)13(18)23/h8,11H,5-7H2,1-4H3,(H2,18,23)(H,19,21,24)/t11-/m0/s1. InChi Key: HBPXWEPKNBHKAX-NSHDSACASA-N.