6-Thioguanine

6-Thioguanine (6-TG) is a thio analog of the purine base guanine that incorporates into DNA during replication, inducing double-strand breaks that destabilize its structure and result in cytotoxicity. Upon incorporation into DNA, 6-TG has been shown to disrupt cytosine methylation by DNA methyltransferases, interfering with the epigenetic pathway of gene regulation. This compound has been used as a chemotherapeutic for acute leukemia and other types of cancer, including BRCA2-mutated tumors.Formal Name: 2-amino-1,9-dihydro-6H-purine-6-thione. CAS Number: 154-42-7. Synonyms: NSC 752, NSC 76504, 6-TG. Molecular Formula: C5H5N5S. Formula Weight: 167.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: 1 M NaOH: 50 mg/ml*. lambdamax: 257, 347 nm. SMILES: NC1=NC(S)=C2C(NC=N2)=N1. InChi Code: InChI=1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11). InChi Key: WYWHKKSPHMUBEB-UHFFFAOYSA-N.