6-diazo-5-oxo-L-nor-Leucine

6-Diazo-5-oxo-L-nor-Leucine (DON) is a glutamine analog that inhibits glutaminases (Ki = 6 µM) and other glutamine-utilizing enzymes, including cytidine triphosphate synthase (CTPS), which uses glutamine in the synthesis of CTP. DON is commonly used in cells or tissues but its use in whole animals is limited by its teratogenicity.Formal Name: 6-diazo-5-oxo-L-norleucine. CAS Number: 157-03-9. Synonyms: DON, NSC 7365. Molecular Formula: C6H9N3O3. Formula Weight: 171.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 1 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 274 nm. SMILES: OC([C@@H](N)CCC(C=[N+]=[N-])=O)=O. InChi Code: InChI=1S/C6H9N3O3/c7-5(6(11)12)2-1-4(10)3-9-8/h3,5H,1-2,7H2,(H,11,12)/t5-/m0/s1. InChi Key: YCWQAMGASJSUIP-YFKPBYRVSA-N.