5'-N-Ethylcarboxamidoadenosine (hydrate)

5'-N-Ethylcarboxamidoadenosine (NECA) is an adenosine analog that acts as an agonist of adenosine receptors (Kis = 1,880, 6,660, and 3.5 nM for human adenosine subtypes A1, A2A, and A3, respectively). NECA is reported to act as a potent vasodilator and can inhibit platelet aggregation by increasing cAMP (EC50 = 3.1 µM).Formal Name: 1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamide, hydrate. Synonyms: Adenosine 5'-ethylcarboxamide, NECA. Molecular Formula: C12H16N6O4 . XH2O. Formula Weight: 308.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 25 mg/ml, DMSO: 14 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 260 nm. SMILES: O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](C(NCC)=O)[C@H]1O.O. InChi Code: InChI=1S/C12H16N6O4.H2O/c1-2-14-11(21)8-6(19)7(20)12(22-8)18-4-17-5-9(13)15-3-16-10(5)18,/h3-4,6-8,12,19-20H,2H2,1H3,(H,14,21)(H2,13,15,16),1H2/t6-,7+,8-,12+,/m0./s1. InChi Key: YMYJSOCTHBLSFF-QCILGFJPSA-N.