103 products were found matching "K04265"!

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat ADORA1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat ADORA1. Next,...

FK-453 is an adenosine A1 receptor antagonist (Ki = 18 nM). It is selective for the adenosine A1 receptor over the adenosine A2A and A3 receptors (Kis = 1,300 and 2,800 nM, respectively). FK-453 reduces adenosine-induced negative inotropic activity in isolated guinea pig atrial strips (IC50 = 560 pM).2 It has...

Description: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. A1AR Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 39.3 kDa and the accession number is P30542.

5'-N-Ethylcarboxamidoadenosine (NECA) is an adenosine analog that acts as an agonist of adenosine receptors (Kis = 1,880, 6,660, and 3.5 nM for human adenosine subtypes A1, A2A, and A3, respectively). NECA is reported to act as a potent vasodilator and can inhibit platelet aggregation by increasing cAMP (EC50 = 3.1...

5'-Deoxy-5'-methylthioadenosine (MTA) is an intermediate in the generation of adenine and methionine that is produced by the decarboxylation of S-adenosylmethionine. This nucleoside is a potent agonist of adenosine receptors (Kis = 0.15, 1.13, 13.9, and 0.68 µM for A1, A2A, A2B, and A3, respectively). At higher...

2-Chloroadenosine (CADO) is a metabolically stable analog of adenosine that binds to adenosine A1, A2A, and A3 receptors with Ki values of 300, 80, and 1,900 nM, respectively. CADO has been used to activate adenosine receptors in the thalamus, generating anticonvulsive activity in a rat model of generalized...

5'-Deoxy-5'-methylthioadenosine-d3 (MTA-d3) is intended for use as an internal standard for the quantification of MTA (Cay-15593) by GC- or LC-MS. MTA is an intermediate in the generation of adenine and methionine that is produced by the decarboxylation of S-adenosylmethionine. This nucleoside is a potent agonist of...

Theobromine is a methylxanthine alkaloid and derivative of caffeine (Cay-14118) that has been found in cocoa beans and has diverse biological activities. It is an adenosine A1 receptor antagonist (IC50s = 200-280 µM in radioligand binding assays using rat brain membranes). Theobromine (150 µg/ml) increases AMPK...

7-Methylxanthine is an adenosine A1 receptor antagonist and active metabolite of theobromine (Cay-21745) and caffeine (Cay-14118). It inhibits binding of the adenosine A1 receptor agonist cyclohexyladenosine in rat cerebral cortical membranes in a concentration-dependent manner. 7-Methylxanthine (300 mg/kg) inhibits...

Description: 4-Methyl-2-oxopentanoic acid is an abnormal metabolite, a neurotoxin and a metabolic toxin. Target: Endogenous Metabolite. Smiles: CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12. References: Avila MA, et al. Methylthioadenosine. Int J Biochem Cell Biol. 2004 Nov,36(11):2125-30.

KW 3902 is an antagonist of the adenosine A1 receptor (Ki = 0.19 nM). It displays 890-fold selectivity for A1 receptors over A2A receptors and has no activity at A3 receptors. KW 3902 less potently inhibits human organic anion transporter 1 (OAT1, Ki = 7.82 µM). KW 3902 exhibits renal protective effects during...