5-Fluorouracil-13C,15N2

5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-fluorouracil (5-FU, (Cay-14416) by GC- or LC-MS. 5-FU is a prodrug form of the thymidylate synthase inhibitor fluorodeoxyuridylate (FdUMP). It is also converted to the active metabolites FUTP and FdUTP, which induce RNA and DNA damage, respectively. In vivo, 5-FU (15 mg/kg) when administered in combination with docetaxel (Cay-11637) reduces tumor growth in B88 and CAL 27 oral squamous cell carcinoma (OSCC) mouse xenograft models. Formulations containing 5-FU have been used in the treatment of colorectal, breast, gastric, and pancreatic cancers.Formal Name: 5-fluoro-2,4(1H,3H)-pyrimidinedione-2-13C-1,3-15N2. CAS Number: 1189423-58-2. Synonyms: 5-FU-13C,15N2. Molecular Formula: C3[13C]H3F[15N2]O2. Formula Weight: 133.1. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble, Methanol: slightly soluble. SMILES: O=C1[15NH][13C]([15NH]C=C1F)=O. InChi Code: InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)/i4+1,6+1,7+1. InChi Key: GHASVSINZRGABV-XZQGXACKSA-N.