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5-Fluorocytosine (5-FC), a fluorinated pyrimidine analog, is a synthetic antimycotic prodrug that is converted by cytosine deaminase to 5-fluorouracil. 5-Fluorouracil, a widely used cytotoxic drug, is further metabolized to fluorinated ribo- and deoxyribonucleotides, resulting in the inhibition of DNA and protein synthesis, which has multiple effects including inhibition of Candida species and C. neoformans infections and cytotoxicity towards cancer cells. In combination with a retroviral replicating vector carrying a cytosine deaminase prodrug-activating gene, 5-FC has been shown to selectively eliminate CT26 and Tu-2449 tumor cells in vitro (IC50s = 4.2 and 1.5 µM, respectively) and to significantly improve survival and reduce tumor size (at a dose of 500 mg/kg) in two different syngeneic mouse glioma models.Formal Name: 6-amino-5-fluoro-2(1H)-pyrimidinone. CAS Number: 2022-85-7. Synonyms: Ancobon, Ancotil, 5-FC, NSC 103805, Ro 2-9915. Molecular Formula: C4H4FN3O. Formula Weight: 129.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 0.2 mg/ml, PBS (pH 7.2): 0.5 mg/ml. lambdamax: 239, 278 nm. SMILES: FC1=CNC(N=C1N)=O. InChi Code: InChI=1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9). InChi Key: XRECTZIEBJDKEO-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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