3-amino Benzamide

3-amino benzamide is an inhibitor of poly(ADP-ribose) polymerase (PARP, IC50 = 5.4 µM in C3H/10T1/2 mouse stem cells). It inhibits spontaneous, as well as FGF2-induced, invasiveness of human umbilical vein endothelial cells (HUVECs) when used at a concentration of 50 µM. 3-amino benzamide (50 µM) induces tubulogenesis and reduces FGF2-induced expression of the gene encoding urokinase-type plasminogen activator (uPA) in HUVECs. It reduces telomere length in HeLaS3 human cervical cancer cells and non-cancerous COM3 hamster cells in a concentration-dependent manner.Formal Name: 3-amino-benzamide. CAS Number: 3544-24-9. Synonyms: m-Aminobenzamide, 3-(Aminocarbonyl) Aniline, 3-Carboxamidoaniline, NSC 36962. Molecular Formula: C7H8N2O. Formula Weight: 136.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 2 mg/ml. lambdamax: 218, 314 nm. SMILES: NC1=CC=CC(C(N)=O)=C1. InChi Code: InChI=1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10). InChi Key: GSCPDZHWVNUUFI-UHFFFAOYSA-N.