24(R)-hydroxy Cholesterol

24(S)-hydroxy Cholesterol is a side-chain substituted oxysterol that is generated from the action of CYP46 on cholesterol found in the brain and plays an important role in cholesterol homeostasis. 24(R)-hydroxy Cholesterol is a synthetic enantiomer of 24(S)-hydroxy cholesterol that activates LXRalpha and LXRbeta nuclear receptors with slightly reduced potency (EC50 = 7 and 4 µM, respectively) compared to the natural isomer (EC50 = 4 and 3 µM, respectively).Formal Name: cholest-5-ene-3beta,24R-diol. CAS Number: 27460-26-0. Synonyms: 24-Epicerebrosterol. Molecular Formula: C27H46O2. Formula Weight: 402.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 100 µg/ml, Ethanol: 20 mg/ml, Ethanol:PBS (pH 7.2): 500 µg/ml. SMILES: O[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CC[C@@H](O)C(C)C. InChi Code: InChI=1S/C27H46O2/c1-17(2)25(29)11-6-18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20+,21+,22-,23+,24+,25-,26+,27-/m1/s1. InChi Key: IOWMKBFJCNLRTC-RNCHBCSGSA-N.