- Search results for K08536
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53 products were found matching "K08536"!
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Item number: ELK-ELK6666.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse LXRa. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse LXRa. Next,...
Keywords: | Lxra, Nr1h3, Liver X receptor alpha, Oxysterols receptor LXR-alpha, Nuclear receptor subfamily 1 group H member 3 |
Application: | ELISA |
Species reactivity: | mouse |
From 365.00€
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Item number: ELK-ELK2764.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human LXRa. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human LXRa. Next,...
Keywords: | LXRA, NR1H3, Liver X receptor alpha, Oxysterols receptor LXR-alpha, Nuclear receptor subfamily 1 group H member 3 |
Application: | ELISA |
Species reactivity: | human |
From 365.00€
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Item number: IB-D00311
Keywords: | Nuclear receptor subfamily 1 group H member 3 |
Application: | Functional activity screening |
Species reactivity: | dog |
1,448.00€
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Item number: Cay10054-1
The liver X receptors, LXRalpha and LXRbeta, are nuclear receptors that act as ligand-dependent transcription factors. They modulate cholesterol, fatty acids, and glucose homeostasis. GW 3965 is an orally-active agonist of LXRalpha and LXRbeta, activating the human isoforms with EC50 values of 190 and 30 nM,...
Keywords: | 3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-benzeneacetic acid, monohydrochloride |
Application: | LXR alpha / beta agonist |
CAS | 405911-17-3 |
MW: | 618.5 D |
From 53.00€
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Item number: Cay14791-1
The liver x receptors (LXRalpha and LXRbeta) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism. 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXRalpha and LXRbeta in...
Keywords: | (25S)-26-hydroxy cholesterol, (25S)-cholest-5-ene-3beta,26-diol |
Application: | LXR alpha / beta activator |
CAS | 56845-83-1 |
MW: | 402.7 D |
From 77.00€
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Item number: Cay71810-50
The Liver X Receptors (LXRalpha and LXRbeta) are nuclear hormone receptors whose native ligands are oxysterols, such as 22(R)-hydroxycholesterol. The LXRs regulate the oxysterol-induced expression of cholesterol 7alpha-hydroxylase, the rate limiting enzyme of classic bile acid synthesis. T0901317 is a potent and...
Keywords: | N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide |
Application: | LXRalpha agonist, LXRbeta agonist |
CAS | 293754-55-9 |
MW: | 481.3 D |
From 54.00€
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Item number: Cay18771-1
The liver X receptors (LXRs) are nuclear receptors that act as ligand-dependent transcription factors. They modulate lipid, cholesterol, and carbohydrate metabolism and homeostasis. SR9238 is an inverse agonist of the two LXR isoforms, LXRalpha and LXRbeta (IC50s = 214 and 43 nM, respectively). It displays liver...
Keywords: | 5-[[[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-2-furancarboxylic... |
Application: | LXRA / LXRB inverse agonist |
CAS | 1416153-62-2 |
MW: | 595.7 D |
From 44.00€
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Item number: Cay14790-5
The liver X receptors (LXRalpha and LXRbeta) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism. 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXRalpha and LXRbeta in...
Keywords: | (25R)-26-hydroxy Cholesterol, (25R)-cholest-5-ene-3beta,26-diol |
Application: | LXR alpha / beta activator |
CAS | 20380-11-4 |
MW: | 402.7 D |
From 77.00€
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Item number: Cay10217-1
24(S)-hydroxy Cholesterol is a side-chain substituted oxysterol that is generated from the action of CYP46 on cholesterol found in the brain and plays an important role in cholesterol homeostasis. 24(R)-hydroxy Cholesterol is a synthetic enantiomer of 24(S)-hydroxy cholesterol that activates LXRalpha and LXRbeta...
Keywords: | 24-Epicerebrosterol, cholest-5-ene-3beta,24R-diol |
Application: | LXR alpha / beta agonist |
CAS | 27460-26-0 |
MW: | 402.7 D |
From 66.00€
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Item number: Cay25443-1
GSK2033 is an antagonist of liver X receptor alpha (LXRalpha) and LXRbeta (IC50s = 0.1 and 0.398 µM, respectively) that has no agonist activity in an LXR transactivation assay. It inhibits LXR agonist-induced and basal expression of the LXR target genes ATP-binding cassette transporter 1 (ABCA1) and sterol...
Keywords: | 2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]-benzenesulfo... |
Application: | LXRalpha / LXRbeta antagonist |
CAS | 1221277-90-2 |
MW: | 591.7 D |
From 43.00€
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Item number: Cay10009931-5
24(S)-hydroxy Cholesterol is a side-chain substituted oxysterol that has important roles in cholesterol homeostasis. It is generated by the action of CYP46 on cholesterol in the brain and diffuses across the blood-brain barrier to the systemic circulation where it can modulate cell signaling, be used for further...
Keywords: | Cerebrosterol, cholest-5-ene-3beta,24S-diol |
Application: | LXR alpha / beta agonist |
CAS | 474-73-7 |
MW: | 402.7 D |
From 92.00€
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Item number: Cay21117-1
LXR-623 is a liver X receptor (LXR) modulator that acts as a partial agonist at LXRalpha and a full agonist at LXRbeta (IC50s = 179 and 24 nM, respectively). It is orally bioavailable and readily passes the blood-brain barrier. LXR-623 is anti-atherogenic in animal models of atherosclerosis, showing synergistic...
Keywords: | WAY-252623, 2-[(2-chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole |
Application: | LXR agonist |
CAS | 875787-07-8 |
MW: | 422.8 D |
From 43.00€
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