2-PMAP

2-PMAP is an inhibitor of the production of amyloid precursor protein (APP) and amyloid-beta (Abeta) secretion. It reduces levels of APP and its intracellular C-terminal fragments alpha-CTF and beta-CTF in CHO APP751SW cells when used at a concentration of 10 µM. 2-PMAP also reduces secretion of Abeta (1-40) and Abeta (1-42) by 88.6 and 84.9%, respectively, in CHO APP751SW cells when used at a concentration of 50 µM without inducing cellular toxicity. In vivo, 2-PMAP reduces brain levels of full-length APP, alpha-CTF and beta-CTF, and soluble Abeta (1-40) and Abeta (1-42) in the APPSWPS1dE9 transgenic mouse model of Alzheimer's disease. It also improves novel object memory as well as spatial memory in the radial arm maze in APPSWPS1dE9 transgenic mice.Formal Name: 2-[(2-pyridinylmethyl)amino]-phenol. CAS Number: 102212-26-0. Molecular Formula: C12H12N2O. Formula Weight: 200.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.33 mg/ml. lambdamax: 245, 293 nm. SMILES: OC1=C(NCC2=CC=CC=N2)C=CC=C1. InChi Code: InChI=1S/C12H12N2O/c15-12-7-2-1-6-11(12)14-9-10-5-3-4-8-13-10/h1-8,14-15H,9H2. InChi Key: GXJRVWZNMZGWAQ-UHFFFAOYSA-N.