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2-Chloroadenosine (CADO) is a metabolically stable analog of adenosine that binds to adenosine A1, A2A, and A3 receptors with Ki values of 300, 80, and 1,900 nM, respectively. CADO has been used to activate adenosine receptors in the thalamus, generating anticonvulsive activity in a rat model of generalized seizures. It has also been used to induce bronchoconstrictor effects in a guinea pig model of asthma and to study cardiovascular responses in normotensive and hypertensive rats.Formal Name: 2-chloro-adenosine. CAS Number: 146-77-0. Synonyms: Antibiotic AT-265B, CADO, NSC 36896. Molecular Formula: C10H12ClN5O4. Formula Weight: 301.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 2.5 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml, Ethanol: 0.25 mg/ml. lambdamax: 210, 264 nm. SMILES: O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=C(Cl)N=C3N)O[C@@H]1CO. InChi Code: InChI=1S/C10H12ClN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6-,9-/m1/s1. InChi Key: BIXYYZIIJIXVFW-UUOKFMHZSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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