2-Aminoethyl diphenylborinate

2-Aminoethyl diphenylborinate (2-APB) is a modulator of intracellular calcium levels and transient receptor potential (TRP) channels. It inhibits calcium release induced by inositol-1,4,5-triphosphate (IP3) in rat cerebellar microsomes (IC50 = 42 µM) without affecting IP3 binding to its receptor. 2-APB inhibits store-operated calcium entry (SOCE) in DT40 cells (IC50 = 4.8 µM), as well as inhibits TRP canonical 6 (TRPC6) and TRP melastatin 8 (TRPM8) and activates TRP vanilloid 1 (TRPV1), TRPV2, and TRPV3 in vitro. It also inhibits calcium transients induced by the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor thapsigargin (Cay-10522) in DDT1 MF-2 cells when used at a concentration of 75 µM. 2-APB inhibits differentiation of primary mouse brown adipocytes when used at concentrations ranging from 30 to 300 µM and reduces adipocyte triglyceride levels at 100 µM. It also increases the expression of Ucp1 and Pparg in primary mouse brown adipocytes. 2-APB (10 mg/kg) reduces protein levels of TRP melastatin 2 (TRPM2) in the rat hippocampus and improves learning and memory deficits induced by amyloid-beta (25-35) in rats.Formal Name: B,B-diphenyl-borinic acid, 2-aminoethyl ester. CAS Number: 524-95-8. Synonyms: 2-Aminoethoxydiphenyl borate, 2-APB, NSC 17107. Molecular Formula: C14H16BNO. Formula Weight: 225.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 0.05 mg/ml. SMILES: [H][N+](CCO1)([H])[B-]1(C2=CC=CC=C2)C3=CC=CC=C3. InChi Code: InChI=1S/C14H16BNO/c1-3-7-13(8-4-1)15(16-11-12-17-15)14-9-5-2-6-10-14/h1-10H,11-12,16H2. InChi Key: QKVRQZFQCGZLDA-UHFFFAOYSA-N.