1-(3-Chlorophenyl)biguanide (hydrochloride)

1-(3-Chlorophenyl)biguanide (m-CPBG) is an agonist of the serotonin (5-HT) receptor subtype 5-HT3. It selectively binds 5-HT3 over 5-HT1A and 5-HT2 receptors (Kis = 0.002, 10, and 10 µM, respectively) but also binds to high and low affinity sites on the dopamine transporter (DAT, IC50s = 0.4 and 34.8 µM, respectively, in rat caudate putamen synaptosomal membranes). m-CPBG induces depolarization of isolated rat vagus nerve and stimulates inositol phosphate formation in rat frontocingulate cortical slices (EC50s = 0.05 and 4.2 µM, respectively). It induces bradycardia, an effect that can be reversed by the 5-HT3 receptor antagonist ondansetron, in anaesthetized cats (ED50 = 20.3 nmol/kg).Formal Name: N-(3-chlorophenyl)-imidodicarbonimidic diamide, monohydrochloride. CAS Number: 2113-05-5. Synonyms: m-Chlorophenylbiguanide hydrochloride, meta-Chlorophenylbiguanide, m-CPBG, meta-CPBG. Molecular Formula: C8H10ClN5 . HCl. Formula Weight: 248.1. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 20 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 257 nm. SMILES: ClC1=CC=CC(NC(NC(N)=N)=N)=C1.Cl. InChi Code: InChI=1S/C8H10ClN5.ClH/c9-5-2-1-3-6(4-5)13-8(12)14-7(10)11,/h1-4H,(H6,10,11,12,13,14),1H. InChi Key: FOWAIJYHRWFTHR-UHFFFAOYSA-N.