Chrysomycin A

Chrysomycin A is an antibiotic isolated from a strain of Streptomyces. It is structurally very similar to gilvocarcin V, an inhibitor of topoisomerase II which promotes DNA cross-linking with histone 3 and GRP78 when photoactivated by near-UV light. Chrysomycin A inhibits DNA synthesis in bacteria and suppresses the growth of transplantable tumors in mice.Formal Name: 4-(6-deoxy-3-C-methyl-beta-gulopyranosyl)-8-ethenyl-1-hydroxy-10,12-dimethoxy-6H-benzo[d]naphtho[1,2-b]pyran-6-one. CAS Number: 82196-88-1. Synonyms: Albacarcin V, NSC 613946, Virenomycin V. Molecular Formula: C28H28O9. Formula Weight: 508.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: soluble, Ethanol: slightly soluble, Methanol: slightly soluble. SMILES: O=C(O1)C2=C(C(OC)=CC(C=C)=C2)C3=C1C4=C(C5O[C@@H](C)[C@@H](O)[C@](C)(O)[C@@H]5O)C=CC(O)=C4C(OC)=C3. InChi Code: InChI=1S/C28H28O9/c1-6-13-9-16-20(18(10-13)34-4)15-11-19(35-5)22-17(29)8-7-14(21(22)23(15)37-27(16)32)24-26(31)28(3,33)25(30)12(2)36-24/h6-12,24-26,29-31,33H,1H2,2-5H3/t12-,24?,25+,26+,28-/m0/s1. InChi Key: OMDANBMKOUVKAG-YROGDRKISA-N. Origin: Bacterium/Streptomyces sp..