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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| BPS-78747 | 1 ml (500 µl x 2) | - | - |
3 - 15 business days* |
1,295.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Notch1dE Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral... more
Product information "Notch1dE Lentivirus"
Notch1dE Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to transduce most mammalian cells, including primary and non-dividing cells. These lentiviruses express a truncated human Notch1 construct (Notch1dE) in which the entire extracellular domain was deleted. The lentiviruses also contain a puromycin selection marker (Figure 1). Once expressed in a cell line of interest, Notch1dE is cleaved by gamma-secretase, resulting in the constitutively active intracellular domain of Notch (NICD). NICD translocates to the nucleus, binds to the transcription factor CSL (CBF1/RBPJkappa/Suppressor of Hairless/Lag-1) and activates transcription of Notch1-responsive genes. When used in combination with CSL (CBF1/RBP-Jk) Luciferase Reporter Lentiviruses (BPS Bioscience #78746), NICD activates the CSL (CBF1/RBPJkappa/Suppressor of Hairless/Lag-1) responsive elements, inducing luciferase expression.
| Keywords: | TAN1, NOTCH1, |
| Supplier: | BPS Bioscience |
| Supplier-Nr: | 78747 |
Properties
| Application: | Notch signaling pathway activity monitoring |
| Species reactivity: | human |
Database Information
| KEGG ID : | K02599 | Matching products |
| UniProt ID : | P46531 | Matching products |
| Gene ID | GeneID 4851 | Matching products |
Handling & Safety
| Storage: | -80°C (avoid repeat freezing and thawing cycles) |
| Shipping: | -80°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
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