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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Colormetric. Detection Range: 0.31-20 ng/mL. Protein function: Lipoprotein-associated... more
Product information "Uncoated Human LpPLA2(Lipoprotein-associated Phospholipase A2) ELISA Kit"
Colormetric. Detection Range: 0.31-20 ng/mL. Protein function: Lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress response (PubMed:7700381, PubMed:8624782, PubMed:2040620, PubMed:16371369, PubMed:17090529, PubMed:10066756). At the lipid- aqueous interface, hydrolyzes the ester bond of fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:2040620, PubMed:10504265). Specifically targets phospholipids with a short-chain fatty acyl group at sn-2 position (PubMed:2040620). Can hydrolyze phospholipids with long fatty acyl chains, only if they carry oxidized functional groups (PubMed:2040620, PubMed:8624782). Hydrolyzes and inactivates platelet-activating factor (PAF, 1-O-alkyl- 2-acetyl-sn-glycero-3-phosphocholine), a potent proinflammatory signaling lipid that acts through PTAFR on various innate immune cells (PubMed:10504265, PubMed:10066756, PubMed:7592717, PubMed:11590221, PubMed:7700381, PubMed:18434304, PubMed:16371369, PubMed:8675689, PubMed:8624782). Hydrolyzes oxidatively truncated phospholipids carrying an aldehyde group at omega position, preventing their accumulation in low-density lipoprotein (LDL) particles and uncontrolled proinflammatory effects (PubMed:2040620, PubMed:7700381). As part of high-density lipoprotein (HDL) particles, can hydrolyze phospholipids having long-chain fatty acyl hydroperoxides at sn-2 position and protect against potential accumulation of these oxylipins in the vascular wall (PubMed:17090529). Catalyzes the release from membrane phospholipids of F2-isoprostanes, lipid biomarkers of cellular oxidative damage (PubMed:16371369). [The UniProt Consortium]
Keywords: | PAFAH, PLA2G7, gVIIA-PLA2, LDL-PLA(2), PAF 2-acylhydrolase, PAF acetylhydrolase, Group-VIIA phospholipase A2, LDL-associated phospholipase A2, Platelet-activating factor acetylhydrolase, 1-alkyl-2-acetylglycerophosphocholine esterase |
Supplier: | Elabscience |
Supplier-Nr: | E-UNEL-H0109 |
Properties
Application: | ELISA |
Species reactivity: | human |
Format: | Solid Phase |
Database Information
KEGG ID : | K01062 | Matching products |
UniProt ID : | Q13093 | Matching products |
Gene ID | GeneID 7941 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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