Thromboxane A Synthase Inhibitor Screening Assay Kit

Cayman's TXAS Inhibitor Screening Assay Kit provides a robust and easy-to-use platform for identifying novel inhibitors of human TXAS. The assay uses a TAMRA-conjugated TXAS-specific probe suitable for fluorescence polarization (FP)-based screening of TXAS inhibitors. Inhibitors of TXAS displace the fluorescent probe from the TXAS active site, leading to a decrease in FP that can be easily quantified using an FP-capable plate reader at excitation and emission wavelengths of 530 and 590 nm, respectively. The potent and reversible TXAS inhibitor ozagrel, or OKY-046, is included as a positive control and inhibits TXAS with an IC50 value of 25-75 nM.Synonyms: CYP5A1, Cytochrome P450 5A1, TBXAS1, TXAS, TXA Synthase. Emission: 590 nm. Excitation: 530 nm. Origin: Animal/Bovine.