JMJD2B Homogeneous Assay kit

The JMJD2B Homogeneous Assay Kit is designed to measure activity of the JMJD2B using purified enzyme complex or cell extracts containing JMJD2B, using AlphaScreen or AlphaLISA technology. JMJD2B is a JmjC-domain protein that exhibits demethylation activity toward H3-K9Me3 and H3-K36Me3. The JMJD2B Homogeneous Assay Kit comes in a convenient format, with a 384-well plate, biotinylated histone H3 peptide substrate, primary antibody, demethylase assay buffer, and purified JMJD2B for 384 enzyme reactions. Great for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications. Ref: 1. Whetstine JR et al. (2006) Cell 125:467. 2. Fodor, B.D., Genes & Dev. 2006. 20: 1557-1562.