Anti-phospho-Tau (Ser214) / MAPT, clone 31M21

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. Phospho-Tau (Ser214) antibody recognizes tau protein (MAPT) phosphorylated at serine 214, a modification with regulatory and pathological significance. Tau normally stabilizes microtubules in neurons, but phosphorylation at Ser214 reduces its ability to bind microtubules, promoting cytoskeletal instability. This site is often phosphorylated by protein kinase A (PKA), linking tau regulation to signaling pathways responsive to cAMP and neurotransmitter activity.Research using Phospho-Tau (Ser214) antibody has shown that phosphorylation at Ser214 occurs during both normal physiology and disease. In healthy neurons, transient phosphorylation at this site facilitates microtubule remodeling required for axonal growth and synaptic plasticity. In neurodegenerative diseases such as Alzheimer's, chronic hyperphosphorylation at Ser214 contributes to tau aggregation and neurofibrillary tangle formation. Its dual role highlights the importance of context when studying Ser214 phosphorylation.Studies have also indicated that Ser214 phosphorylation may act as a priming event for subsequent phosphorylation at neighboring sites, amplifying tau pathology. Elevated levels of phospho-tau (Ser214) have been detected in human brain tissue from Alzheimer's patients and animal models, supporting its value as a biomarker of disease progression. Because it integrates signals from kinases like PKA and stress pathways, this phosphorylation event provides insight into how extracellular stimuli influence tau pathology.Antibodies specific to tau phosphorylated at Ser214 are validated for western blot, immunohistochemistry, and immunofluorescence. These reagents allow selective detection of the phosphorylated form, enabling studies of neuronal signaling, tau biology, and drug development. Clone-validated antibodies ensure reproducibility across clinical and experimental settings.NSJ Bioreagents supplies this Phospho-Tau (Ser214) antibody for neuroscience research, neurodegenerative disease studies, and therapeutic development.