Anti-phospho-Tau (Ser202) / MAPT, clone 31M22

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. Phospho-Tau (Ser202) antibody detects Tau protein phosphorylated at serine 202, encoded by the MAPT gene. Tau is a microtubule associated protein that stabilizes neuronal microtubules and regulates axonal transport. Phospho-Tau (Ser202) antibody provides researchers with a critical reagent to study neurodegeneration, Alzheimer disease, and tauopathies associated with abnormal Tau phosphorylation.Tau normally binds and stabilizes microtubules in axons, promoting neuronal structure and intracellular transport. Research using Phospho-Tau (Ser202) antibody has shown that phosphorylation at Ser202 reduces Tau binding to microtubules, leading to destabilization and cytoskeletal disorganization. This modification is an early hallmark of pathological Tau in Alzheimer disease.Studies with Phospho-Tau (Ser202) antibody have revealed that hyperphosphorylation at Ser202 and neighboring residues contributes to Tau aggregation into neurofibrillary tangles. These aggregates impair neuronal function and survival, driving neurodegeneration. Detection of Ser202 phosphorylation therefore provides an important marker for disease progression in tauopathies.In Alzheimer disease, Phospho-Tau (Ser202) antibody has demonstrated strong immunoreactivity in affected brain regions such as the hippocampus and cortex. This phosphorylation is mediated by kinases including GSK3 beta and CDK5, linking Tau pathology to signaling pathways dysregulated in disease. Monitoring Ser202 phosphorylation offers insight into how signaling cascades contribute to neuronal dysfunction.Beyond Alzheimer disease, Tau phosphorylation at Ser202 is implicated in other neurodegenerative conditions such as progressive supranuclear palsy, corticobasal degeneration, and frontotemporal dementia. Research using Phospho-Tau (Ser202) antibody has shown that this site is consistently phosphorylated across tauopathies, making it a reliable disease marker.Phospho-Tau (Ser202) antibody is widely used in immunohistochemistry, western blotting, and immunofluorescence. Immunohistochemistry highlights phosphorylated Tau aggregates in brain tissue, western blotting distinguishes pathological from normal isoforms, and immunofluorescence demonstrates subcellular accumulation in neurons. These approaches make the antibody essential for neurodegeneration research.By supplying validated Phospho-Tau (Ser202) antibody reagents, NSJ Bioreagents supports studies into Alzheimer disease, tauopathies, and neuronal dysfunction. Detection of Tau phosphorylated at Ser202 provides insight into the molecular events driving neurodegeneration.