Anti-phospho-Tau (Ser199) / MAPT, clone 31M19

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. Phospho-Tau (Ser199) antibody recognizes tau protein (MAPT) when phosphorylated at serine 199, a modification associated with neurodegenerative disease. Tau is a microtubule-associated protein that stabilizes cytoskeletal structure in neurons. In Alzheimer's disease and related tauopathies, abnormal phosphorylation of tau at multiple sites, including Ser199, leads to microtubule destabilization and the formation of neurofibrillary tangles.Research employing Phospho-Tau (Ser199) antibody has shown that phosphorylation at this site correlates with early pathological changes in Alzheimer's models. Ser199 phosphorylation is regulated by kinases such as GSK-3beta and CDK5, linking tau pathology to altered kinase activity. Monitoring this specific phosphorylation event provides valuable insight into mechanisms of neuronal dysfunction and progression of tau-related diseases.Antibodies directed against phospho-tau (Ser199) are validated for applications including western blot, immunofluorescence, and immunohistochemistry. They allow researchers to discriminate between total tau and phosphorylated tau, supporting studies of disease biomarkers, kinase regulation, and therapeutic intervention strategies. Clone validation ensures specificity for the phosphorylated residue, avoiding cross-reactivity with non-modified tau.NSJ Bioreagents offers this Phospho-Tau (Ser199) antibody to support investigations into Alzheimer's disease, tauopathies, and neuronal cytoskeletal regulation. Alternate names include MAPT antibody, microtubule-associated protein tau antibody, and paired helical filament antibody.