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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
600-401-K09S | 25 µl | - | - |
6 - 10 business days* |
180.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Anti-SMAD2 pS465 pS467 antibody is directed against the phosphorylated form of human Smad2... more
Product information "Anti-phospho-SMAD2 (Ser465/Ser467)"
Anti-SMAD2 pS465 pS467 antibody is directed against the phosphorylated form of human Smad2 protein at the pS465 and pS467 residues. The product was affinity purified from monospecific antiserum by immunoaffinity purification. Antiserum was first purified against the phosphorylated form of the immunizing peptide. The resultant affinity purified antibody was then cross adsorbed against the non-phosphorylated form of the immunizing peptide. Reactivity occurs against human SMAD2. Reactivity with non-phosphorylated human Smad2 is minimal by ELISA and western blot. A BLAST analysis was used to suggest cross-reactivity with Smad2 protein from human, mouse, rat, orangutan, and bovine based on 100% homology with the immunizing sequence. Reactivity against homologues from other sources is not known. Protein function: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. [The UniProt Consortium]
Keywords: | Anti-phospho-Smad2, Anti-phospho-MADH2, Anti-phospho-SMAD2, Anti-phospho-hMAD-2, Anti-phospho-JV18-1, Anti-phospho-SMAD 2, Anti-phospho-hSMAD2, Anti-phospho-MAD homolog 2, Anti-phospho-SMAD family member 2, Anti-phospho-Mad-related protein 2 |
Supplier: | Rockland Immunochemicals |
Supplier-Nr: | 600-401-K09S |
Properties
Application: | ELISA, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | synthetic peptide corresponding to a C-terminal of human SMAD2 protein. |
Format: | Purified |
Database Information
KEGG ID : | K04500 | Matching products |
UniProt ID : | Q15796 | Matching products |
Gene ID | GeneID 4087 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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