Anti-phospho-PZR, (Tyr263) (Myelin Protein Zero-like Protein 1, Protein Zero-related, MPZL1, UNQ849

Anti-phospho-PZR, (Tyr263) (Myelin Protein Zero-like Protein 1, Protein Zero-related, MPZL1, UNQ849
Item number Size Datasheet Manual SDS Delivery time Quantity Price
P9580-20.100 100 µl - -

1 - 19 business days

543.00€
 
PZR (Protein zero related) is an immunoglobulin superfamily protein that specifically binds the... more
Product information "Anti-phospho-PZR, (Tyr263) (Myelin Protein Zero-like Protein 1, Protein Zero-related, MPZL1, UNQ849"
PZR (Protein zero related) is an immunoglobulin superfamily protein that specifically binds the tyrosine phosphatase SHP-2 through its intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs) (1,2). PZR is phosphorylated by c-Src, c-Fyn, c-Lyn, Csk, and c-Abl (3). PP1, a Src family kinase inhibitor, inhibits PZR phosphorylation (4,5). There are three alternatively spliced isoforms designated as PZR, PZRa, and PZRb, both PZRa and PZRb lack ITIMs (6,7). PZR is a main receptor of ConA and has an important role in cell signaling via c-Src (4). PZR is expressed in many cell types and is localized to cell contacts and intracellular granules in BAECs and mesothelioma (REN) cells. Recently, PZR has been implicated as a cell adhesion protein that may be involved in SHP-2-dependent signaling at interendothelial cell contacts (3). Hypertyrosine phosphorylation of PZR was observed during embryogenesis in a mouse model of Noonan Syndrome (8). Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:1000, Immunoprecipitation: 1:50, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-Protein zero-related, Anti-Myelin protein zero-like protein 1
Supplier: United States Biological
Supplier-Nr: P9580-20

Properties

Application: IP, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Bovine, Human, Mouse, Rat
Immunogen: Synthetic peptide corresponding to residues surrounding Tyr263 of human PZR.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-phospho-PZR, (Tyr263) (Myelin Protein Zero-like Protein 1, Protein Zero-related, MPZL1, UNQ849"
Write a review
or to review a product.
Information about the product reference will follow. more
Viewed