Anti-phospho-PDX1 (Thr11)

Anti-phospho-PDX1 (Thr11)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-F48610-0.08ML 80 µl - -

3 - 10 business days*

326.00€
NSJ-F48610-0.4ML 400 µl - -

3 - 10 business days*

702.00€
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. PDX1 is a transcriptional activator of several genes,... more
Product information "Anti-phospho-PDX1 (Thr11)"
In 1X PBS, pH 7.4, with 0.09% sodium azide. PDX1 is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this protein are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). Protein function: Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer, the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. [The UniProt Consortium]
Keywords: Anti-phospho-GSF, Anti-phospho-IPF1, Anti-phospho-PDX1, Anti-phospho-IPF-1, Anti-phospho-PDX-1, Anti-phospho-IDX-1, Anti-phospho-IUF-1, Anti-phospho-STF-1, Anti-phospho-Glucose-sensitive factor, Anti-phospho-Insulin upstream factor 1, Phospho-PDX1 Antibod
Supplier: NSJ Bioreagents
Supplier-Nr: F48610

Properties

Application: IF, Dot Blot, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: This phospho-PDX1 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pT11 of human PDX1.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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