Anti-phospho-PBL / Phospholamban (Phospho-T17)

In 1X PBS, pH 7.4, with 0.09% sodium azide. Phospholamban is a small protein found in the sarcoplasmic reticulum of cardiac muscle cells, where it plays a crucial role in regulating the calcium ion concentration and ultimately the contraction of the heart muscle. Phosphorylated phospholamban is a form of the protein that has undergone a chemical modification in which phosphate groups are added to specific amino acid residues. This modification has been found to alter the interaction of phospholamban with other proteins and enzymes in the cell, leading to changes in calcium handling and cardiac contractility. Studies have demonstrated that phosphorylated phospholamban can enhance the function of the sarcoplasmic reticulum calcium pump, which is responsible for pumping calcium ions out of the cell after each contraction. This increased activity results in improved relaxation of the heart muscle and overall cardiac function. Furthermore, research has shown that abnormalities in phosphorylated phospholamban levels are associated with various cardiac conditions, including heart failure and arrhythmias. Protein function: Reversibly inhibits the activity of ATP2A2/SERCA2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+) (PubMed:28890335). Binds preferentially to the ATP- bound E1 conformational form of ATP2A2 which predominates at low Ca(2+) concentrations during the diastolic phase of the cardiac cycle. Inhibits ATP2A2 Ca(2+) affinity by disrupting its allosteric activation by ATP. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. Also inhibits the activity of ATP2A3/SERCA3. Controls intracellular Ca(2+) levels in elongated spermatids and may play a role in germ cell differentiation. In the thalamic reticular nucleus of the brain, plays a role in the regulation of sleep patterns and executive functioning. [The UniProt Consortium]