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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
600-401-C84 | 100 µl | - | - |
6 - 10 business days* |
684.00€
|
Anti-MEK 1/2 pS218/pS222 antibodies are affinity purified from monospecific antiserum by... more
Product information "Anti-phospho-MEK1/2 (Ser218/Ser222)"
Anti-MEK 1/2 pS218/pS222 antibodies are affinity purified from monospecific antiserum by immunoaffinity purification. Immunolabeling is blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide. Expect reactivity with the following species based on sequence homology: bovine, canine, chicken, human, non-human primates, rat, Xenopus and zebra fish. Cross reactivity with MEK 1/2 pS218/pS222 from other species has not been determined. Protein function: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator- activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. [The UniProt Consortium]
Keywords: | Anti-phospho-MEK1, Anti-phospho-MKK1, Anti-phospho-MEK 1, Anti-phospho-MAP2K1, Anti-phospho-MAPKK 1, EC=2.7.12.2, Anti-phospho-MAPK/ERK kinase 1, Anti-phospho-MAP kinase kinase 1, Anti-phospho-ERK activator kinase 1 |
Supplier: | Rockland Immunochemicals |
Supplier-Nr: | 600-401-C84 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | synthetic phospho-peptide corresponding to amino acid residues surrounding Ser218/222 conjugated to KLH. |
Format: | Purified |
Database Information
KEGG ID : | K04368 | Matching products |
UniProt ID : | Q02750 | Matching products |
Gene ID | GeneID 5604 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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