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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| ARG20527.50 | 50 µl | - | - |
6 - 14 business days* |
586.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Serine/threonine-protein kinase that plays an essential role in the regulation... more
Product information "Anti-phospho-LIMK1 (Thr508)"
Protein function: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11832213, PubMed:12807904, PubMed:15660133, PubMed:16230460, PubMed:18028908, PubMed:22328514, PubMed:23633677). Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop (PubMed:10436159). LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly (PubMed:18028908). Stimulates axonal outgrowth and may be involved in brain development (PubMed:18028908). [The UniProt Consortium]
| Keywords: | Anti-phospho-LIMK, Anti-phospho-LIMK1, Anti-phospho-LIMK-1, Anti-phospho-LIMK-1, Anti-phospho-LIM domain kinase 1, Anti-phospho-LIM domain kinase 1 |
| Supplier: | Arigo Biolaboratories |
| Supplier-Nr: | ARG20527 |
Properties
| Application: | ELISA, WB |
| Antibody Type: | Polyclonal |
| Conjugate: | No |
| Host: | Rabbit |
| Species reactivity: | human, mouse, rat |
| Immunogen: | Phosphospecific peptide (coupled to carrier protein) around Thr508 of human LIMK1 protein. This sequence is conserved in rat and mouse LIMK1, and has high homology to Thr505 in human LIMK2 |
| MW: | 73 kD |
| Format: | Antigen Affinity Purified |
Database Information
| KEGG ID : | K05743 | Matching products |
| UniProt ID : | P53667 | Matching products |
| Gene ID : | GeneID 3984 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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