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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
I8700-05N1.100 | 100 µg | - | - |
3 - 19 business days* |
947.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
IRS1 (Insulin Receptor Substrate 1) transmits insulin signals via metabolic and mitogenic... more
Product information "Anti-phospho-IRS1, (Ser307 mouse/ Ser312 human) (insulin receptor substrate 1)"
IRS1 (Insulin Receptor Substrate 1) transmits insulin signals via metabolic and mitogenic pathways. IRS1 is heavily phosphorylated on both serine and tyrosine residues. These phosphorylated tyrosines enable IRS to act as a docking protein that binds SH2 domains of such proteins as PI3 Kinase (phosphatidylinositol 3-kinase) and GRB2, resulting in activation. Over expression and phosphorylation of serine is associated with insulin resistance and breast cancer. Some of the more notable phosphorylation sites are Ser302 that is phosphorylated following insulin stimulation. Ser307, phosphorylated by JNK and IKK, is a key regulatory site that appears to disrupt the IRS1/IR interaction and inhibits insulin-mediated activation of the PI3 kinase and MAPK pathways, and Ser636/639 that is known to be phosphorylated by p70S6K downstream of mTOR and acts as a negative feedback loop. Applications: Suitable for use in Immunofluorescence, Western Blot, Immunoprecipitation, and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000, Immunocytochemistry: 1:500, Immunoprecipitation: 1:1000, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | Anti-phospho-IRS-1, Anti-phospho-Insulin receptor substrate 1 |
Supplier: | United States Biological |
Supplier-Nr: | I8700-05N1 |
Properties
Application: | ICC, IF, IP, WB |
Antibody Type: | Monoclonal |
Clone: | 9H250 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human, mouse, rat |
Immunogen: | Synthetic peptide corresponding to amino acids surrounding phosphorylated Ser307 of mouse IRS1. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K16172 | Matching products |
UniProt ID : | P35568 | Matching products |
Gene ID | GeneID 3667 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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