Anti-phospho-Histone H2A.X, (Ser139/Tyr142) (H2a/x, H2AFX, H2AX)

Anti-phospho-Histone H2A.X, (Ser139/Tyr142) (H2a/x, H2AFX, H2AX)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
H5110-03W.100 100 µl - -

4 - 22 business days

543.00€
 
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap... more
Product information "Anti-phospho-Histone H2A.X, (Ser139/Tyr142) (H2a/x, H2AFX, H2AX)"
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. [The UniProt Consortium]
Keywords: Anti-phospho-Histone H2A.x
Supplier: United States Biological
Supplier-Nr: H5110-03W

Properties

Application: FC, IF, IP, WB
Antibody Type: Polyclonal
Host: Rabbit
Reactivity: Human, Monkey, Mouse, Rat
Immunogen: Synthetic phosphopeptide corresponding to residues surrounding the phosphorylated Ser139 and Tyr142 of human H2A.X.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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