Anti-phospho-FOXP3 (Ser418)

Anti-phospho-FOXP3 (Ser418)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-F48635-0.08ML 80 µl - -

3 - 10 business days*

326.00€
NSJ-F48635-0.4ML 400 µl - -

3 - 10 business days*

702.00€
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. The protein is a member of the forkhead/winged-helix... more
Product information "Anti-phospho-FOXP3 (Ser418)"
In 1X PBS, pH 7.4, with 0.09% sodium azide. The protein is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Protein function: Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon- gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (PubMed:17360565). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049). Inhibits the transcriptional activator activity of RORA (PubMed:18354202). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4. [The UniProt Consortium]
Keywords: Anti-phospho-JM2, Anti-phospho-IPEX, Anti-phospho-FOXP3, Phospho-FOXP3 Antibody (pS418)
Supplier: NSJ Bioreagents
Supplier-Nr: F48635

Properties

Application: Dot Blot, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: This phospho-FOXP3 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS418 of human FOXP3.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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