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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
C0013-02C.100 | 100 µl | - | - |
3 - 19 business days* |
757.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The c-Abl proto-oncogene encodes a nonreceptor protein tyrosine kinase that is ubiquitously... more
Product information "Anti-phospho-c-Abl, (Tyr89) (ABL1, v-abl, Abelson Murine Leukemia Viral Oncogene Homolog 1, ABL, c-A"
The c-Abl proto-oncogene encodes a nonreceptor protein tyrosine kinase that is ubiquitously expressed and highly conserved in metazoan evolution. c-Abl protein is distributed in both the nucleus and the cytoplasm of cells. It is implicated in regulating cell proliferation, differentiation, apoptosis, cell adhesion and stress responses (1-3). c-Abl kinase activity is increased in vivo by diverse physiological stimuli including integrin activation, PDGF stimulation and binding to c-Jun, Nck and RFX1 (2,4). The in vivo mechanism of regulation of c-Abl kinase activity is not completely understood. Tyr245 is located in the linker region between the SH2 and catalytic domains. This positioning is conserved among Abl family members. Phosphorylation of Tyr245 is involved in the activation of c-Abl kinase (5). In addition, phosphorylation of Tyr412, which is located in the kinase activation loop of c-Abl, is required for kinase activity (6)., Phosphorylation of c-Abl on Tyr89 was identified using LC-MS/MS platform for phosphorylation site discovery as well as another publication using MS technology (7). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000, incubate membrane with diluted primary antibody in 5% BSA, 1X TBS, 0.1% Tween 20 at 4°C with gentle shaking, overnight., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-phospho-ABL, Anti-phospho-p150, Anti-phospho-JTK7, Anti-phospho-ABL1, EC=2.7.10.2, Anti-phospho-Proto-oncogene c-Abl, Anti-phospho-Tyrosine-protein kinase ABL1, Anti-phospho-Abelson tyrosine-protein kinase 1, Anti-phospho-Abelson murine leukemia vira |
Supplier: | United States Biological |
Supplier-Nr: | C0013-02C |
Properties
Application: | WB |
Antibody Type: | Monoclonal |
Clone: | 10g161(61A6) |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Synthetic phosphopeptide corresponding to residues surrounding Tyr89 of human c-Abl. |
Format: | Supernatant |
Database Information
KEGG ID : | K06619 | Matching products |
UniProt ID : | P00519 | Matching products |
Gene ID | GeneID 25 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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