Anti-phospho-ATF2 (Ser112 or 94)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG51537.50 50 µl - -

6 - 14 business days*

436.00€
ARG51537.100 100 µl - -

6 - 14 business days*

624.00€
 
Protein function: Transcriptional activator which regulates the transcription of various genes,... more
Product information "Anti-phospho-ATF2 (Ser112 or 94)"
Protein function: Transcriptional activator which regulates the transcription of various genes, including those involved in anti- apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. [The UniProt Consortium]
Keywords: Anti-phospho-ATF2, Anti-phospho-HB16, Anti-phospho-CREB2, Anti-phospho-CREB-2, Anti-phospho-Histone acetyltransferase ATF2, Anti-phospho-Activating transcription factor 2, Anti-phospho-cAMP-responsive element-binding protein 2
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG51537

Properties

Application: WB, IHC (paraffin)
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: Peptide sequence around phosphorylation site of serine 112 or 94 (D-L-S(p)-P-L) derived from Human ATF2
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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