Anti-phospho-AMPA Receptor 1 (Ser831), clone 32G40

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. Phospho-AMPA Receptor 1 (Ser831) antibody detects AMPA receptor subunit GluA1 when phosphorylated at serine 831, a modification critical for synaptic plasticity. AMPA receptors are glutamate-gated ion channels that mediate fast excitatory neurotransmission in the central nervous system. Phosphorylation of GluA1 at Ser831 by CaMKII or PKC increases channel conductance, strengthening synaptic transmission during processes such as long-term potentiation (LTP).Research using Phospho-AMPA Receptor 1 (Ser831) antibody has shown that this modification plays a key role in learning and memory. Ser831 phosphorylation enhances calcium permeability and receptor function, promoting LTP in hippocampal neurons. Disruption of this phosphorylation event impairs memory consolidation and cognitive performance in animal models. It is therefore a crucial target for studies of synaptic plasticity and higher-order brain function.Dysregulation of Ser831 phosphorylation has been implicated in neurodegenerative diseases, psychiatric disorders, and addiction. In Alzheimer's disease models, impaired AMPA receptor phosphorylation contributes to synaptic dysfunction and memory loss. Abnormal regulation of GluA1 phosphorylation has also been observed in schizophrenia and depression, linking it to disrupted glutamatergic signaling. In addiction research, Ser831 phosphorylation is modulated by repeated drug exposure, altering synaptic plasticity and reward circuitry.Antibodies against phospho-AMPA receptor 1 (Ser831) are validated for immunohistochemistry, immunofluorescence, and western blot. These reagents allow selective detection of the phosphorylated receptor, supporting studies of neuronal signaling, synaptic strength, and disease-related changes. Clone-based antibodies ensure specificity to the Ser831 site, avoiding cross-reactivity with unmodified AMPA receptors.NSJ Bioreagents offers this Phospho-AMPA Receptor 1 (Ser831) antibody for neuroscience research focused on learning, memory, and synaptic disorders.