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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay17855-1 | 1 each | - |
6 - 10 business days* |
664.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Histone H3 is a nuclear protein and a component of the nucleosome core that is essential for... more
Product information "Anti-Histone H3 (Citrullinated Arg2 + Arg8 + Arg17)"
Histone H3 is a nuclear protein and a component of the nucleosome core that is essential for organizing genomic DNA in eukaryotic nuclei. It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications, including citrullination. Histone H3 is subject to citrullination of arginine residues by peptidyl arginine deiminase 4 (PAD4) at positions 2, 8, 17 and 26, and this citrullination blocks methylation of these residues by protein-arginine methyltransferase 4 (PRMT4) and induces transcriptional repression of target genes. Citrullinated histone H3 is a component of neutrophil extracellular traps (NETs) that acts as an autoantigen to induce production of anti-citrullinated protein antibodies associated with various diseases such as sepsis, multiple sclerosis, rheumatoid arthritis, and multiple myeloma. Cayman's Histone H3 (Citrullinated R2 + R8 + R17) Polyclonal Antibody can be used for ELISA and Western blot applications. The antibody recognizes citrullinated histone H3 at 16 kDa from human samples.Immunogen: Histone H3 peptide with citrullinations at R2, R8, and R17. Formulation: (Request formulation change), 500 µl of peptide affinity-purified polyclonal antibody. Storage Buffer: TBS, pH 7.4, with 50% glycerol, 0.1% BSA, and 0.02% sodium azide. Host: Rabbit. Applications: ELISA, WB. Cross Reactivity: (-) Non-citrullinated H3.
Keywords: | Anti-citrullinated-H3FH (Citrullinated R2 + R8 + R17), Anti-citrullinated-H3FK, Anti-citrullinated-H3FI, Anti-citrullinated-H3FD, Anti-citrullinated-H3FF, Anti-citrullinated-H3FB, Anti-citrullinated-H3FJ, Anti-citrullinated-H3FA, Anti-citrullinated-H3FL, |
Supplier: | Cayman Chemical |
Supplier-Nr: | 17855 |
Properties
Application: | ELISA, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Histone H3 peptide with citrullinations at R2, R8, and R17 |
Format: | Solid |
Database Information
KEGG ID : | K11253 | Matching products |
UniProt ID : | P68431 | Matching products |
Gene ID : | GeneID 8350 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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