Anti-Histone H3 (Citrullinated Arg2 + Arg8 + Arg17)

Anti-Histone H3 (Citrullinated Arg2 + Arg8 + Arg17)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay17855-1 1 each -

6 - 10 business days*

499.00€
 
Histone H3 is a nuclear protein and a component of the nucleosome core that is essential for... more
Product information "Anti-Histone H3 (Citrullinated Arg2 + Arg8 + Arg17)"
Histone H3 is a nuclear protein and a component of the nucleosome core that is essential for organizing genomic DNA in eukaryotic nuclei. It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications, including citrullination. Histone H3 is subject to citrullination of arginine residues by peptidyl arginine deiminase 4 (PAD4) at positions 2, 8, 17 and 26, and this citrullination blocks methylation of these residues by protein-arginine methyltransferase 4 (PRMT4) and induces transcriptional repression of target genes. Citrullinated histone H3 is a component of neutrophil extracellular traps (NETs) that acts as an autoantigen to induce production of anti-citrullinated protein antibodies associated with various diseases such as sepsis, multiple sclerosis, rheumatoid arthritis, and multiple myeloma. Cayman's Histone H3 (Citrullinated R2 + R8 + R17) Polyclonal Antibody can be used for ELISA and Western blot applications. The antibody recognizes citrullinated histone H3 at 16 kDa from human samples. Immunogen: Histone H3 peptide with citrullinations at R2, R8, and R17. Formulation: 500 µl of peptide affinity-purified IgG. Storage Buffer: TBS, pH 7.4, with 50% glycerol, 0.1% BSA, and 0.02% sodium azide. Host: Rabbit. Applications: ELISA, WB. Cross Reactivity: (-) Non-citrullinated H3.
Keywords: Anti-citrullinated-H3FH (Citrullinated R2 + R8 + R17), Anti-citrullinated-H3FK, Anti-citrullinated-H3FI, Anti-citrullinated-H3FD, Anti-citrullinated-H3FF, Anti-citrullinated-H3FB, Anti-citrullinated-H3FJ, Anti-citrullinated-H3FA, Anti-citrullinated-H3FL,
Supplier: Cayman Chemical
Supplier-Nr: 17855

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: Histone H3 peptide with citrullinations at R2, R8, and R17
Format: Solid

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H316, H319
P Phrases: P264, P280, P305+351+338, P332+313, P337+313
Caution
Our products are for laboratory research use only: Not for administration to humans!
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