Anti-Histone H1.4 (Citrullinated Arg53)

Anti-Histone H1.4 (Citrullinated Arg53)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay18073-1 1 each -

6 - 10 business days*

412.00€
 
Citrullinated histone H1.4 is a citrullinated form of histone H1.4, a nuclear protein that... more
Product information "Anti-Histone H1.4 (Citrullinated Arg53)"
Citrullinated histone H1.4 is a citrullinated form of histone H1.4, a nuclear protein that interacts with linker DNA regions between nucleosomes to provide nucleosome core structure stabilization. Histone H1 subtypes are comprised of a short N-terminal domain, a central globular domain necessary for DNA interaction, and long C-terminal domain that determines subtype binding properties by its variability. Histone H1.4 is expressed in most somatic cell types and is essential for survival of T47D and MCF-7 breast cancer cells and MCF-10A breast epithelial cells. It is subject to citrullination by protein-arginine deiminase 4 (PAD4) at arginine 54, which corresponds to arginine 53 of the immunizing peptide for Cayman's Histone H1.4 (Citrullinated R53) Polyclonal Antibody. Citrullination releases histone 1 from chromatin, leading to chromatin decondensation in mouse embryonic stem cells. Cayman's Histone H1.4 (Citrullinated R53) Polyclonal Antibody can be used for Western blot applications. The antibody recognizes citrullinated histone H1, and not unmodified H1, at 35 kDa from human samples. Immunogen: Synthetic peptide from human Histone H1.4 citrullinated at R53. Formulation: 500 µl of peptide affinity-purified antibody. Storage Buffer: TBS, pH 7.4, with 50% glycerol, 0.1% BSA, and 0.02% sodium azide. Host: Rabbit. Applications: WB. Cross Reactivity: (-) Non-citrullinated histone H1.
Keywords: Anti-citrullin-H1F4 (Citrullinated R53), Anti-citrullin-HIST1H1E, Anti-citrullin-Histone H1b, Anti-citrullin-Histone H1.4, Anti-citrullin-Histone H1s-4, Citrullination
Supplier: Cayman Chemical
Supplier-Nr: 18073

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: Synthetic peptide from human Histone H1.4 citrullinated at R53
Format: Solid

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H316, H319
P Phrases: P264, P280, P305+351+338, P332+313, P337+313
Caution
Our products are for laboratory research use only: Not for administration to humans!
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