Anti-CREB (Phospho-Ser133)

It is well known that the control of gene expression involves activation of protein kinase cascades that regulate transcription factors within the nucleus. The cyclic AMP response element binding protein (CREB) is one of the best characterized stimulus-induced transcription factors. This transcription factor is a component of intracellular signaling events that regulate a wide range of biological functions, from spermatogenesis to circadian rhythms and memory. A variety of protein kinases including protein kinase A (PKA), mitogen-activated protein kinases (MAPKs), and Ca2+/calmodulin-dependent protein kinases (CaMKs) phosphorylate CREB at serine 133 (Ser133), and phosphorylation of Ser133 is required for CREB-mediated transcription.Immunogen: Synthetic peptide from amino acid residues surrounding the phospho-Ser133 of rat CREB. MW: 45 kDa. Formulation: (Request formulation change), 100 µl of affinity-purified polyclonal antibody. Storage Buffer: 10 mM HEPES, pH 7.5, with 150 mM sodium chloride, 100 µg/ml BSA, and 50% glycerol. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) Rat CREB. Origin: Animal/Rabbit.