Anti-ZNF207

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A305-814A-T	10 µl (10 µg)		-		3 - 7 business days*		165.00€
A305-814A	100 µl (100 µg)		-		3 - 7 business days*		586.00€

If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk

Protein function: Kinetochore- and microtubule-binding protein that plays a key role in spindle... more

Close menu

Product information "Anti-ZNF207"

Protein function: Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187). [The UniProt Consortium]

Keywords:	Anti-BuGZ, Anti-hBuGZ, Anti-Zinc finger protein 207, Anti-BUB3-interacting and GLEBS motif-containing protein ZNF207
Supplier:	Bethyl Laboratories
Supplier-Nr:	A305-814A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse (Expected: orangutan)
Format:	Antigen Affinity Purified