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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| ELK-ES19896.50 | 50 µl | - | - |
10 - 14 business days* |
173.00€
|
||
| ELK-ES19896.100 | 100 µl | - | - |
10 - 14 business days* |
290.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: E3 SUMO-protein ligase, has a preference for SUMO2 and SUMO3 and facilitates... more
Product information "Anti-ZN451"
Protein function: E3 SUMO-protein ligase, has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation. Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483). [The UniProt Consortium] Recommended dilutions: WB 1:1000-2000. Cellular localization: Nucleus . Nucleus, PML body . Nucleus, nucleoplasm. Colocalizes with UBE2I/UBC9, SUMO1 and SUMO2 in nuclear granules, this probably requires sumoylation. Desumoylation leads to diffuse nucleoplasmic location. .
| Keywords: | Anti-ZNF451, Anti-Zinc finger protein 451, Anti-E3 SUMO-protein ligase ZNF451, Anti-Coactivator for steroid receptors, Anti-E3 SUMO-protein transferase ZNF451, ZN451 rabbit pAb |
| Supplier: | ELK Biotechnology |
| Supplier-Nr: | ES19896 |
Properties
| Application: | WB |
| Antibody Type: | Polyclonal |
| Conjugate: | No |
| Host: | Rabbit |
| Species reactivity: | human, mouse |
| Immunogen: | Synthesized peptide derived from human ZN451 AA range: 222-272 |
| Format: | Purified |
Database Information
| KEGG ID : | K25176 | Matching products |
| UniProt ID : | Q9Y4E5 | Matching products |
| Gene ID : | GeneID 26036 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
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