Anti-ZMYM3

This gene is located on the X chromosome and is subject to X inactivation. It is highly conserved in vertebrates and most abundantly expressed in the brain. The encoded protein is a component of histone deacetylase-containing multiprotein complexes that function through modifying chromatin structure to keep genes silent. A chromosomal translocation (X,13) involving this gene is associated with X-linked mental retardation. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2010], Protein function: Plays a role in the regulation of cell morphology and cytoskeletal organization. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000. Cellular localization: Nucleus .