Anti-Zebrafish Tollip / Toll-Interacting Protein

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Predicted to enable ubiquitin binding activity and ubiquitin conjugating enzyme binding activity. Acts upstream of or within negative regulation of Wnt signaling pathway. Predicted to be located in early endosome. Predicted to be active in cytoplasm. Orthologous to human TOLLIP (toll interacting protein). Protein function: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates. In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes. Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P). [The UniProt Consortium]